Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

Autor:	Sandy Ma, Jin-Quan Yu, Giorgio Villa, Anna Homs, Peter S. Thuy-Boun
Rok vydání:	2013
Předmět:	inorganic chemicals Chemistry organic chemicals chemistry.chemical_element General Chemistry General Medicine Deuterium Benzoates Carbon Catalysis Organic chemistry Reactivity (chemistry) Palladium Hydrogen Phenylacetates
Zdroj:	Angewandte Chemie. 126:753-756
ISSN:	0044-8249
DOI:	10.1002/ange.201305388
Popis:	We disclose a protocol for the palladium-catalyzed ortho-selective C-H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination.
Databáze:	OpenAIRE
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