Peripheral nerve diffusion tensor imaging as a measure of disease progression in ALS
| Autor: | Jim Lagopoulos, Susanna B. Park, Robert D. Henderson, Casey M. M. Pfluger, Matthew C. Kiernan, Neil G. Simon, Steve Vucic, Michel Kliot, Thomas A. Gallagher, James Howells, Sita Paling |
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| Rok vydání: | 2017 |
| Předmět: |
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medicine.medical_specialty Neurology Statistics as Topic Neural Conduction Severity of Illness Index Lower motor neuron 030218 nuclear medicine & medical imaging Disability Evaluation 03 medical and health sciences 0302 clinical medicine Internal medicine Fractional anisotropy Image Processing Computer-Assisted medicine Humans Motor unit number estimation Longitudinal Studies Peripheral Nerves Amyotrophic lateral sclerosis Tibial nerve Aged business.industry Amyotrophic Lateral Sclerosis Middle Aged medicine.disease Surgery Compound muscle action potential Diffusion Tensor Imaging medicine.anatomical_structure Cardiology Anisotropy Female Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Neurology. 264:882-890 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-017-8443-x |
| Popis: | Clinical trial design in amyotrophic lateral sclerosis (ALS) remains hampered by a lack of reliable and sensitive biomarkers of disease progression. The present study evaluated peripheral nerve diffusion tensor imaging (DTI) as a surrogate marker of axonal degeneration in ALS. Longitudinal studies were undertaken in 21 ALS patients studied at 0 and 3 months, and 19 patients at 0, 3 and 6 months, with results compared to 13 age-matched controls. Imaging metrics were correlated across a range of functional assessments including amyotrophic lateral sclerosis functional rating scale revised (ALSFRS-R), lower limb muscle strength (Medical Research Council sum score, MRCSS-LL), compound muscle action potential amplitudes and motor unit number estimation (MUNE). Fractional anisotropy was reduced at baseline in ALS patients in the tibial (p |
| Databáze: | OpenAIRE |
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