Umbilical Blood Levels of IL-6 and TNF-α as Predictors of the Central Nervous System Damage and Retinopathy in Preterm Infants
| Autor: | Danielius Serapinas, Daiva Bartkevičienė, Ieva Narkevičiūtė, Brigita Vaigauskaitė, Irena Dumalakienė, Agnė Bartkevičiūtė, Rasa Aurelija Vankevičiūtė, Ingrida Pilypienė |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Central nervous system Gestational Age Umbilical cord Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Retinopathy of Prematurity Prospective Studies Interleukin 6 Proportional Hazards Models 030219 obstetrics & reproductive medicine biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Infant Newborn Obstetrics and Gynecology Retinopathy of prematurity medicine.disease Fetal Blood Vascular endothelial growth factor A medicine.anatomical_structure Intraventricular hemorrhage Pediatrics Perinatology and Child Health biology.protein Gestation Female business Biomarkers Infant Premature Retinopathy |
| Zdroj: | American journal of perinatology. 38(10) |
| ISSN: | 1098-8785 |
| Popis: | Objective The aim was to identify the critical levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A in umbilical cord blood that could be used as markers for predicting the central nervous system (CNS) damage and retinopathy of prematurity (ROP) in preterm infants. Study Design A total of 158 preterm infants, born at 22 to 34 weeks of gestation, were evaluated in the first week after birth and at 36 to 37 weeks of postconceptual age. Results A significant relationship between CNS changes and concentrations of IL-6 (p 13.0 pg/mL predicts significant CNS damages in 36 to 37-week infants (p = 0.013). ROP was diagnosed in 24.8% infants (n = 149). It was detected that the levels of TNF-α >116.4 pg/mL (p 13.0 pg/mL (p Conclusion Critical values of IL-6 and TNF-α in predicting ≥grade III intraventricular hemorrhage in the early adaptation and in predicting marked CNS damages and severe ROP stages in the later adaptation of preterm infants were determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|