Neural basis of associative learning in Trichotillomania and skin-picking disorder
| Autor: | Darin D. Dougherty, Amy T. Peters, Jon E. Grant, Tara S. Peris, Emily J. Ricketts, Marta Migó, Tina Chou, Joseph O’Neill, Dan J. Stein, Christine Lochner, Nancy Keuthen, John Piacentini, Thilo Deckersbach |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Adolescent 1.2 Psychological and socioeconomic processes 1.1 Normal biological development and functioning Cognitive flexibility Basic Behavioral and Social Science Medical and Health Sciences Article Trichotillomania Young Adult Behavioral Neuroscience Clinical Research Underpinning research Associative learning Behavioral and Social Science Humans Functional neuroimaging Neurology & Neurosurgery Psychology and Cognitive Sciences Neurosciences Brain Bayes Theorem Middle Aged Magnetic Resonance Imaging Brain Disorders Skin-picking disorder Mental Health Neurological Female |
| Zdroj: | Behav Brain Res |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2022.113801 |
| Popis: | Disorders such as Trichotillomania (TTM) and skin-picking disorder (SPD) are associated with reduced flexibility and increased internally focused attention. While the basal ganglia have been hypothesized to play a key role, the mechanisms underlying learning and flexible accommodation of new information is unclear. Using a Bayesian Learning Model, we evaluated the neural basis of learning and accommodation in individuals with TTM and/or SPD. Participants were 127 individuals with TTM and/or SPD (TTM/SPD) recruited from three sites (age 18-57, 84% female) and 26 healthy controls (HC). During fMRI, participants completed a shape-button associative learning and reversal fMRI task. Above-threshold clusters were identified where the Initial Learning-Reversals BOLD activation contrast differed significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect