Omega Fatty Acids and Inflammatory Bowel Diseases: An Overview

Autor: Sandra Maria Barbalho, Ledyane Taynara Marton, Antonelly Cassio Alves de Carvalho, Ricardo de Alvares Goulart
Rok vydání: 2019
Předmět:
0301 basic medicine
eicosapentaenoic acid
medicine.medical_specialty
Review
Disease
Gastroenterology
Catalysis
Proinflammatory cytokine
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
ulcerative colitis
Crohn's disease
Gastrointestinal tract
business.industry
Research
Fatty Acids
Organic Chemistry
Inflammatory Bowel Diseases
General Medicine
docosahexaenoic acid
medicine.disease
Ulcerative colitis
Eicosapentaenoic acid
omega 3
Computer Science Applications
crohn’s disease
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Docosahexaenoic acid
030211 gastroenterology & hepatology
Disease Susceptibility
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4851 (2019)
ISSN: 1422-0067
Popis: Inflammatory bowel diseases (IBD) are chronic, inflammatory processes that affect the gastrointestinal tract and are mainly represented by ulcerative colitis (UC) and Crohn’s disease (CD). Omega 3 (ω3) fatty acids (eicosapentanoic acid and docosahexaenoic acid) show an indispensable role in the inflammatory processes and, for these reasons, we aimed to review the effects of these acids on UC and CD. Databases such as PUMED and EMBASE were searched, and the final selection included fifteen studies that fulfilled the inclusion criteria. The results showed that ω3 fatty acids reduce intestinal inflammation, induce and maintain clinical remission in UC patients, and are related with the reduction of proinflammatory cytokines, decrease disease activity and increase the quality of life of CD patients. Furthermore, the consumption of these fatty acids may be related to a reduced risk of developing IBD. Many studies have shown the beneficial effects of ω3 as adjunctive in the treatment or prevention of UC or CD. Nevertheless, most were performed with a small number of patients and there are many variations in the mode of consumption, the type of food or the type of formulation used. All these factors substantially interfere with the results and do not allow reliable comparisons.
Databáze: OpenAIRE
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