Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils

Autor: Shijun Wang, Patrick H. Maxwell, Mathieu-Benoit Voisin, Sussan Nourshargh, Lydia Sorokin, Christoph Scheiermann, Maxine G. B. Tran, John A. Dangerfield, Karen Y. Larbi
Rok vydání: 2006
Předmět:
Leukocyte migration
Neutrophils
Immunology
Integrin
Perlecan
Biology
Extracellular Matrix Proteins/genetics
Basement Membrane/physiology
Article
Basement Membrane
Extracellular matrix
Mice
03 medical and health sciences
0302 clinical medicine
Venules
Cell Movement
Laminin
Leukocytes
medicine
Neutrophils/physiology
Animals
Immunology and Allergy
Muscle
Skeletal

GeneralLiterature_REFERENCE(e.g.
dictionaries
encyclopedias
glossaries)

DNA Primers
030304 developmental biology
Basement membrane
Leukocytes/physiology
Extracellular Matrix Proteins
0303 health sciences
Venule
Reverse Transcriptase Polymerase Chain Reaction
Elastase
Venules/physiology
Cell Biology
Articles
Molecular biology
Cell biology
Mice
Inbred C57BL

medicine.anatomical_structure
Gene Expression Regulation
biology.protein
Muscle
Skeletal/blood supply

030217 neurology & neurosurgery
030215 immunology
Zdroj: The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 203, No 6 (2006) pp. 1519-1532
ISSN: 1540-9538
0022-1007
DOI: 10.1084/jem.20051210
Popis: The mechanism of leukocyte migration through venular walls in vivo is largely unknown. By using immunofluorescence staining and confocal microscopy, the present study demonstrates the existence of regions within the walls of unstimulated murine cremasteric venules where expression of key vascular basement membrane (BM) constituents, laminin 10, collagen IV, and nidogen-2 (but not perlecan) are considerably lower (
Databáze: OpenAIRE