Generation of the Thymine Triplet State by Through-Bond Energy Transfer
| Autor: | Paula Miro, M. Consuelo Cuquerella, German Sastre, Miguel A. Miranda, M. Luisa Marin, Miguel Gomez-Mendoza |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Generalitat Valenciana |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Photochemistry Energy transfer Organic Chemistry Laser flash photolysis General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Thymine chemistry.chemical_compound QUIMICA ORGANICA chemistry Computational chemistry QUIMICA ANALITICA DNA damage Steroids Triplet state Bond energy |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Popis: | Benzophenone (BP) and drugs containing the BP chromophore, such as the non-steroidal anti-inflammatory drug ketoprofen, have been widely reported as DNA photosensitizers through triplet–triplet energy transfer (TTET). In the present work, a direct spectroscopic fingerprint for the formation of the thymine triplet ( Thy*) by through-bond (TB) TTET from BP* has been uncovered. This has been achieved in two new systems that have been designed and synthesized with one BP and one thymine (Thy) covalently linked to the two ends of the rigid skeleton of the natural bile acids cholic and lithocholic acid. The results shown here prove that it is possible to achieve triplet energy transfer to a Thy unit even when the photosensitizer is at a long (nonbonding) distance. Financial support from the Spanish Government (Grant SEV‐2016‐0683 and Projects CTQ2012‐38754‐C03‐03 and CTQ2015‐70164P), the Generalitat Valenciana (Prometeo Program), and the Universitat Politècnica de València (pre‐doctoral FPI fellowship for P.M.) is gratefully acknowledged. |
| Databáze: | OpenAIRE |
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