Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively
| Autor: | Keri E. Cannon, Lindsay B. Hough, Rob Leurs |
|---|---|
| Přispěvatelé: | Medicinal chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Clinical Biochemistry Histamine Antagonists Toxicology Biochemistry Article Histamine agonist Histamine Agonists Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Nerve Fibers Piperidines Formaldehyde Internal medicine Peripheral Nervous System medicine Animals Edema Receptors Histamine H3 Neurons Afferent Injections Spinal Biological Psychiatry Pain Measurement Skin Inflammation Nerve Endings Pharmacology Thioperamide Behavior Animal Imidazoles Brain Immepip Rats Nociception Endocrinology Spinal Cord chemistry Systemic administration Histamine H3 receptor Histamine medicine.drug |
| Zdroj: | Pharmacology, Biochemistry and Behavior, 88(1), 122-9. Elsevier Inc. Cannon, K E, Leurs, R & Hough, L H 2007, ' Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively ', Pharmacology, Biochemistry and Behavior, vol. 88, no. 1, pp. 122-9 . https://doi.org/10.1016/j.pbb.2007.07.014 |
| ISSN: | 0091-3057 |
| Popis: | Pharmacological activation of histamine H 3 receptors is known to reduce the release of inflammatory peptides, thereby reducing pain and inflammation, but the site(s) and mechanism(s) of these effects are currently unknown. The present study addressed these questions by examining the effects of the H 3 agonist immepip and the H 3 antagonist thioperamide on nociceptive behaviors and swelling produced during the rat formalin test. Systemic administration of immepip (5 and 30 mg/kg, s.c.) significantly attenuated formalin-induced flinching but not licking responses during both phases. This attenuation was reversed by either systemic (15 mg/kg, i.p.) or intrathecal (20 or 50 μg) administration of thioperamide. Furthermore, immepip (30 mg/kg, s.c.) significantly inhibited formalin-induced swelling, an action which was completely reversed by systemic (15 mg/kg, i.p.), but not intrathecal (50 μg) thioperamide. Also consistent with this pattern, intrathecal immepip (50 μg) reduced flinching responses, but had no effect on formalin-induced paw swelling. The present findings suggest that activation of H 3 receptors located on peripheral and spinal terminals of deep dermal fibers attenuates formalin-induced swelling and flinching, respectively. Pharmacological stimulation of H 3 receptors could be an important therapeutic approach for many disorders related to deep dermal or inflammatory pain. |
| Databáze: | OpenAIRE |
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