Role of eosinophilic granulocytes in women with infertility and pelvic adhesions
| Autor: | Per Venge, Kjeld Fredens, Greta A. B. Edelstam |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Infertility Pathology medicine.medical_specialty medicine.drug_class Biopsy Immunology Fimbria Cell Count Tissue Adhesions Inflammation Biology Monoclonal antibody Pelvis Ribonucleases Eosinophilic medicine Ascitic Fluid Humans Immunology and Allergy Eosinophil degranulation Fallopian Tubes Laparotomy Eosinophil cationic protein Blood Proteins Eosinophil Granule Proteins respiratory system medicine.disease Staining Eosinophils Female medicine.symptom Infertility Female Granulocytes Pelvic Inflammatory Disease |
| Zdroj: | Inflammation. 18:361-371 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/bf01534434 |
| Popis: | Increased numbers of eosinophilic granulocytes and eosinophil degranulation have been observed in various inflammatory conditions. Biopsies from the fallopian tubes of 28 patients were examined for the content of eosinophilic granulocytes. Peritoneal fluids (PF) from 89 patients were analyzed for the concentrations of eosinophilic granulocytes and the granule protein eosinophil cationic protein (ECP). The ECP levels in the PF were substantially elevated during genital inflammation (P < 0.001). Furthermore, one week after laparotomy for adhesiolysis there were both increased PF-ECP levels (P < 0.01) and raised concentrations of eosinophilic granulocytes (P < 0.001) when compared to the reference group. Staining of the biopsies with monoclonal antibodies revealed an increased total number as well as a number of activated eosinophilic granulocytes in specimens from adhesions and sactosalpinx compared to specimens from normal fimbriae. The findings indicate that eosinophilic granulocytes may have a possible role in the fibrotic process of pelvic adhesion disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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