Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism
| Autor: | Azizah Alanazi, Ramesa Shafi Bhat, Naima Zayed, Nada M. Merghani, Abeer Al-Dbass, Afaf El-Ansary, Nadine M. S. Moubayed, Kawther Aabed, Norah Algahtani |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Clinical chemistry Autism Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Alpha (ethology) Propolis 03 medical and health sciences 0302 clinical medicine Endocrinology Neuroinflammation Internal medicine Animals Medicine Autistic Disorder lcsh:RC620-627 Brain Chemistry Inflammation Mesocricetus business.industry Research Biochemistry (medical) Correction Interleukin Propionic acid Disease Models Animal lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Cytokine Bee pollen Dysbiosis Pollen Cytokines Tumor necrosis factor alpha Propionates business 030217 neurology & neurosurgery |
| Zdroj: | Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-8 (2019) Lipids in Health and Disease |
| ISSN: | 1476-511X |
| DOI: | 10.1186/s12944-019-1150-0 |
| Popis: | BackgroundNeuroinflammation plays a major role in the pathogenesis of autism because the cytokine levels are typically disturbed in the brain in autistic patients. Prebiotics-rich diet maintains the healthy gut microbiota and hence can regulate the neuroinflammation indirectly. The study aimed to investigate the role of bee pollen and propolis in ameliorating neuroinflammation, including cytokine levels, in an animal model of autism.MethodsHamsters were classified as four groups: Group I, control; Group II, autistic model/animals treated with 250 mg propionic acid (PPA)/kg body weight (BW)/day for 3 days; Group III, animals treated with bee pollen at a dose of 250 mg/kg BW/day for 4 weeks; and Group IV, animals treated with propolis at a dose of 250 mg/kg BW/day for 4 weeks. Neuroinflammatory responses were evaluated using the levels of interferon γ (IFN-γ), interleukin 1 alpha (IL-1α), IL-6, IL-10, IL-12 (p70), vascular endothelial growth factor (VEGF), and tumor necrosis factor α (TNFα).ResultsSignificant decrease of IL-10 (PPPPPPPPConclusionsOur findings indicate that both bee pollen and propolis protect against neuroinflammation in the rodent model of autism. However, further studies are needed to investigate the clinical benefits of prebiotics-rich diet in neurodevelopmental disorders, such as autism. |
| Databáze: | OpenAIRE |
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