Pathology and Epidemiology of Ceruminous Gland Tumors among Endangered Santa Catalina Island Foxes (Urocyon littoralis catalinae) in the Channel Islands, USA
| Autor: | Calvin L. Duncan, Patricia M. Gaffney, David K. Garcelon, Walter M. Boyce, Julie L. King, Deana L. Clifford, T. Winston Vickers |
|---|---|
| Přispěvatelé: | Thamm, Douglas |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty General Science & Technology Population Ear infection Foxes lcsh:Medicine Ear neoplasm California parasitic diseases Mite medicine Animals Ear External education lcsh:Science Ear Neoplasms Islands Mites education.field_of_study Ceruminous gland Hyperplasia Multidisciplinary biology Endangered Species lcsh:R Ear biology.organism_classification medicine.disease External Neuroendocrine Tumors Otitis Dysplasia population characteristics lcsh:Q medicine.symptom Ear mite Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 11, p e0143211 (2015) BASE-Bielefeld Academic Search Engine PloS one, vol 10, iss 11 PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | In this study, we examined the prevalence, pathology, and epidemiology of tumors in free-ranging island foxes occurring on three islands in the California Channel Islands, USA. We found a remarkably high prevalence of ceruminous gland tumors in endangered foxes (Urocyon littoralis catalinae) occurring on Santa Catalina Island (SCA)--48.9% of the dead foxes examined from 2001-2008 had tumors in their ears, and tumors were found in 52.2% of randomly-selected mature (≥ 4 years) foxes captured in 2007-2008, representing one of the highest prevalences of tumors ever documented in a wildlife population. In contrast, no tumors were detected in foxes from San Nicolas Island or San Clemente Island, although ear mites (Otodectes cynotis), a predisposing factor for ceruminous gland tumors in dogs and cats, were highly prevalent on all three islands. On SCA, otitis externa secondary to ear mite infection was highly correlated with ceruminous gland hyperplasia (CGH), and tumors were significantly associated with the severity of CGH, ceruminous gland dysplasia, and age group (older foxes). We propose a conceptual model for the formation of ceruminous gland tumors in foxes on SCA that is based on persistent, ubiquitous infection with ear mites, and an innate, over exuberant inflammatory and hyperplastic response of SCA foxes to these mites. Foxes on SCA are now opportunistically treated with acaricides in an attempt to reduce mite infections and the morbidity and mortality associated with this highly prevalent tumor. |
| Databáze: | OpenAIRE |
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