Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection
| Autor: | Adithya Sridhar, Inés García-Rodríguez, Dasja Pajkrt, Katja C. Wolthers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
intestinal monolayer 030106 microbiology lcsh:QR1-502 3d model Review Computational biology Biology Models Biological Viral infection lcsh:Microbiology Cell Line Intestine-on-a-Chip 03 medical and health sciences Transwell® Lab-On-A-Chip Devices Virology Organoid enteroid Humans Intestinal Mucosa Enteric virus Barrier function host-virus interactions Gut-on-a-Chip Intestinal organoids intestinal organoid enteric virus Intestines Organoids 030104 developmental biology Infectious Diseases Cellular heterogeneity Virus Diseases Host-Pathogen Interactions Viral studies |
| Zdroj: | Viruses, Vol 12, Iss 1288, p 1288 (2020) Viruses |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v12111288 |
| Popis: | The knowledge about enteric viral infection has vastly increased over the last eight years due to the development of intestinal organoids and enteroids that suppose a step forward from conventional studies using cell lines. Intestinal organoids and enteroids are three-dimensional (3D) models that closely mimic intestinal cellular heterogeneity and organization. The barrier function within these models has been adapted to facilitate viral studies. In this review, several adaptations (such as organoid-derived two-dimensional (2D) monolayers) and original intestinal 3D models are discussed. The specific advantages and applications, as well as improvements of each model are analyzed and an insight into the possible path for the field is given. |
| Databáze: | OpenAIRE |
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