Oxidative Stress: Promoter of Allergic Sensitization to Protease Allergens?
| Autor: | Ronald van Ree, Leonie S. van Rijt, L. Utsch, René Lutter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteases Allergy allergic sensitization Review medicine.disease_cause Catalysis Inorganic Chemistry Allergic sensitization 03 medical and health sciences 0302 clinical medicine Immune system Allergen immune system diseases medicine Hypersensitivity Animals Physical and Theoretical Chemistry Molecular Biology Spectroscopy Sensitization reactive oxygen species Chemistry Immunogenicity Organic Chemistry General Medicine Allergens respiratory system medicine.disease Computer Science Applications respiratory tract diseases Oxidative Stress 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Immunology Oxidative stress |
| Zdroj: | International Journal of Molecular Sciences |
| DOI: | 10.3390/ijms18061112 |
| Popis: | Allergies arise from aberrant T helper type 2 responses to allergens. Several respiratory allergens possess proteolytic activity, which has been recognized to act as an adjuvant for the development of a Th2 response. Allergen source-derived proteases can activate the protease-activated receptor-2, have specific effects on immune cells by cleaving cell membrane-bound regulatory molecules, and can disrupt tight junctions. The protease activity can induce a non-allergen-specific inflammatory response in the airways, which will set the stage for an allergen-specific Th2 response. In this review, we will discuss the evidence for the induction of oxidative stress as an underlying mechanism in Th2 sensitization to proteolytic allergens. We will discuss recent data linking the proteolytic activity of an allergen to its potential to induce oxidative stress and how this can facilitate allergic sensitization. Based on experimental data, we propose that a less proficient anti-oxidant response to allergen-induced oxidative stress contributes to the susceptibility to allergic sensitization. Besides the effect of oxidative stress on the immune response, we will also discuss how oxidative stress can increase the immunogenicity of an allergen by chemical modification. |
| Databáze: | OpenAIRE |
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