Gingival cell growth with antiresorptive treatment combined with corticosteroids or antiestrogen
| Autor: | Tero Soukka, Eliisa Löyttyniemi, Heidi M. Ekholm, Jaana Rautava |
|---|---|
| Přispěvatelé: | Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki University Hospital Area |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
bisphosphonate
corticosteroid medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Estrogen Receptor Modulators Adrenal Cortex Hormones medicine Humans Viability assay Fibroblast General Dentistry Cell Proliferation Diphosphonates oral mucosa Cell growth business.industry denosumab RK1-715 Original Articles 030206 dentistry Bisphosphonate Antiestrogen 313 Dentistry 3. Good health Denosumab medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Dentistry Cancer research antiestrogen Original Article Keratinocyte business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Clinical and Experimental Dental Research, Vol 7, Iss 4, Pp 465-473 (2021) Clinical and Experimental Dental Research |
| ISSN: | 2057-4347 |
| Popis: | Objectives: Antiresorptive treatment has been shown to impair mucosal cell proliferation, migration, and viability. However, in the clinic, antiresorptives are often used in combination with other drugs. We studied the effect of antiresorptives combined with a corticosteroid or antiestrogen on oral mucosal keratinocytes and fibroblasts. Material and methods: Human gingival keratinocyte and fibroblast cell lines were exposed to bisphosphonates (BPs) and denosumab in different concentrations and durations together with an antiestrogen or corticosteroid. Changes in cell viability, proliferation and migration after exposures were measured. Data were evaluated with hierarchical linear mixed model for repeated measurements. Results: Bisphosphonate exposure suppressed keratinocyte and fibroblast cell viability, proliferation, and migration in a time-dependent manner. Combining a corticosteroid or antiestrogen with BPs further increased this negative effect. Denosumab alone had a mild positive effect on keratinocyte and fibroblast growth. When denosumab was combined with a corticosteroid or antiestrogen, cell growth was suppressed. Conclusions: Our results show that coexisting medications may increase the negative impact of BPs or denosumab on oral mucosal cells. |
| Databáze: | OpenAIRE |
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