Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling–Weaning Period
| Autor: | Masako Nakatani, Takamitsu Tsukahara, Ryo Inoue, Kikuto Fukuta, Shozo Tomonaga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Monocarboxylic Acid Transporters hindgut fermentation Swine animal diseases Lumen (anatomy) lcsh:TX341-641 digestive system Article Veins 03 medical and health sciences Animal science Occludin Abdomen medicine Weaning Animals Intestinal Mucosa Vein Cecum suckling chemistry.chemical_classification Nutrition and Dietetics biology Symporters Chemistry weaning Short-chain fatty acid digestive oral and skin physiology 0402 animal and dairy science absorption from lumen food and beverages 04 agricultural and veterinary sciences Blood flow Fatty Acids Volatile 040201 dairy & animal science 030104 developmental biology medicine.anatomical_structure Monocarboxylate transporter 1 Intestinal Absorption Fermentation Propionate biology.protein lipids (amino acids peptides and proteins) Hindgut fermentation short-chain fatty acid lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 10 Issue 9 Nutrients, Vol 10, Iss 9, p 1220 (2018) |
| ISSN: | 2072-6643 |
| Popis: | Luminal short-chain fatty acids (SCFA) are rapidly absorbed from the intestine and subsequently utilized by the host as substrate for metabolic energy production. In pigs, the energy contribution of SCFA is thought to be 30&ndash 76%. However, since absorption and blood flow dynamics of SCFA in pigs, particularly during the suckling&ndash weaning period, remain unclear, we aimed to elucidate these phenomena. Thirty-two piglets were used in the present work. Cecal vein blood and digesta, and portal and abdominal vein blood were sampled from suckling (7-, 14-, 21- and 28-day-old) and weaned (weaning at 21 and 28 days of age) piglets. Four piglets from each group were euthanized. SCFA concentrations in blood samples were analyzed by a highly sensitive gas chromatography-mass spectrometry technique. Age at weaning tended to affect SCFA absorption. For example, acetate and propionate concentrations in the cecal vein tended to be higher in piglets weaned at day 21 than at day 28. SCFA concentrations in the abdominal vein tended to differ from those in other veins. Mucosal gene expression analysis suggested that monocarboxylate transporter 1 and occludin were associated in absorption of SCFA from the lumen into the blood of piglets. |
| Databáze: | OpenAIRE |
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