Clinical outcomes after the use of complete autologous oral mucosa equivalents: preliminary cases
| Autor: | Lucas de Villalaín, Sara Llames, Juan Carlos de Vicente, Santiago Llorente, Ignacio Peña, Luis Junquera |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Keratinocytes
medicine.medical_specialty Medicina Cell Culture Techniques Dentistry Fibrin Tissue Adhesive Transplantation Autologous Pathology and Forensic Medicine Scaffold Autologous plasma Tongue Tissue scaffolds medicine Humans Regeneration Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Oral mucosa Cells Cultured Biología y Biomedicina Skin Tissue Engineering Tissue Scaffolds business.industry Mouth Mucosa Reconstruction transplants Membranes Artificial Fibroblasts Surgery Transplantation stomatognathic diseases medicine.anatomical_structure Tissue-Engineered mucosa Oral epithelium Mouth Neoplasms Oral Surgery business Sheets |
| Zdroj: | e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid instname |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.tripleo.2011.07.030 |
| Popis: | Objective Previously, we reported how to obtain complete autologous oral mucosa equivalents (CAOMEs) composed of an autologous plasma scaffold and fibroblasts together with immature keratinocytes able to build an oral epithelium with a structure similar to that of the oral mucosa. In this study, we present the clinical outcomes after applying our CAOMEs as grafts. Study Design Four patients who needed a CAOME to restore a defect of oral mucosa were selected. Two of the patients suffered from ankyloglossia, and the other 2 required a restoration of the keratinized gum of the alveolar rim. To assess the outcomes, the scale designed by Ewers et al. was used. Results Clinical and functional improvements were achieved in the patients with ankyloglossia. In cases of gum restoration, the mucosa was regenerated and a prosthetic restoration with implants was achieved. Conclusions The results obtained points to the potential use of CAOME in intraoral lining. |
| Databáze: | OpenAIRE |
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