Chagas' Disease: Decreased Resistance to Trypanosoma Cruzi Acquired Infection in Offspring of Infected Mice
| Autor: | M. T. Rivera, Eric Van Marck, Jocelyne Flament, Viviane De Maertelaer, Marta Ontivero, Carine Truyens, Yves Carlier |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Chagas disease Offspring Ratón Trypanosoma cruzi Maternal-Fetal Exchange -- immunology Mice Sex Factors Immune system Pregnancy Trypanosoma cruzi -- immunology Virology parasitic diseases medicine Animals Lactation Chagas Disease Maternal-Fetal Exchange Analysis of Variance Mice Inbred BALB C Chi-Square Distribution biology Mortality rate Immunologic Deficiency Syndromes Sciences bio-médicales et agricoles biology.organism_classification medicine.disease Chagas Disease -- mortality Infectious Diseases Chagas Disease -- immunology Chronic Disease Immunology Linear Models Protozoa Female Parasitology Trypanosomiasis |
| Zdroj: | The American journal of tropical medicine and hygiene, 46 (2 The American journal of tropical medicine and hygiene |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | The course of Trypanosoma cruzi infection was studied in an experimental model, using the offspring of mice that were chronically infected with T. cruzi. When infected two months after birth, a higher mortality rate in heavily parasitized mice occurred in these offspring than in controls born to uninfected mothers. The harmful maternal influence reached a maximum when offspring were exposed both to prenatal (placental) and postnatal (lactating) influences. It was a reversible phenomenon that led to a T. cruzi-specific failure of the offspring to control the acute phase of the infection. Such features are suggestive of a maternally-induced impairment of the immune response of the offspring. Journal Article Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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