Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach
| Autor: | Thibaut Sesia, Veerle Visser-Vandewalle, Philippos Koulousakis, Daniel L.A. van den Hove |
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| Přispěvatelé: | Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Deep brain stimulation Transgene medicine.medical_treatment Deep Brain Stimulation Rat model BETA Stimulation Pilot Projects Disease Motor Activity Nucleus basalis nucleus basalis of Meynert Presenilin Open field intermittent stimulation 03 medical and health sciences 0302 clinical medicine Cognition Alzheimer Disease Amyloid precursor protein Medicine Animals Humans NEURONS Spatial Memory biology business.industry General Neuroscience General Medicine Alzheimer's disease Barnes maze Electrodes Implanted Rats Psychiatry and Mental health Clinical Psychology 030104 developmental biology Basal Nucleus of Meynert biology.protein Geriatrics and Gerontology Rats Transgenic Post implantation business Neuroscience 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Journal of Alzheimer's Disease, 73(2), 461-466. IOS Press |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | BackgroundDeep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown to have promising results in a pilot study with patients suffering from Alzheimer’s disease (AD). A recent study in aged monkeys shows a novel intermittent stimulation pattern to have superior cognitive benefits over continuous paradigms.Objective/HypothesisWe aimed at comparing the cognitive effects elicited by intermittent and continuous NBM stimulation paradigms in an animal model for AD (TgF344-AD rat line; TG), i.e. rats expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD.MethodsIn this exploratory study, aged APP/PS1 rats were tested pre-, and post implantation with several stimulation parameters, i.e. unilateral- or bilateral-intermittent, and bilateral-continuous, while performing various behavioral tasks (open field, novel object recognition, and modified Barnes maze).Results and ConclusionBilateral-intermittent NBM DBS allowed aged TG rats to perform better and maintain their performance longer in a spatial memory task, as compared to other conditions. These data support the notion that NBM DBS could be further refined in the clinic, thereby improving patient care. |
| Databáze: | OpenAIRE |
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