Anti-Inflammatory and Anti-Urolithiasis Effects of Polyphenolic Compounds from Quercus gilva Blume
| Autor: | Hye Shin Ahn, Sung Hye Youn, Joo Hee Kwon, Le Thi Tam, Min Won Lee, Soon Chul Myung, Jun Yin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Ethylene Glycol
030232 urology & nephrology Anti-Inflammatory Agents Pharmaceutical Science 01 natural sciences Antioxidants Analytical Chemistry Mice Quercus 0302 clinical medicine Urolithiasis Drug Discovery Gene expression biology Traditional medicine Molecular Structure Chemistry anti-urolithiasis Proanthocyanidin Chemistry (miscellaneous) Molecular Medicine Cytokines Quercus gilva medicine.drug_class Anti-inflammatory Article Proinflammatory cytokine Quercus gilva Blume anti-oxidation anti-inflammation polyphenol lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry In vivo medicine Animals Humans Physical and Theoretical Chemistry 010405 organic chemistry Plant Extracts Organic Chemistry Polyphenols Evergreen biology.organism_classification 0104 chemical sciences Disease Models Animal RAW 264.7 Cells Gene Expression Regulation Polyphenol Medicine Traditional |
| Zdroj: | Molecules; Volume 22; Issue 7; Pages: 1121 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 22, Iss 7, p 1121 (2017) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules22071121 |
| Popis: | Quercus gilva Bume (QGB, family Fagaceae) is a tall evergreen oak species tree that grows in warm temperate regions in Korea, Japan, China and Taiwan. Quercus plants have long been the basis of traditional medicines. Their clinical benefits according to traditional medicine include relief of urolithiasis, tremors and inflammation. In the present study, the anti-urolithiasis activity including anti-inflammatory and anti-oxidative activities, of some phenolic compounds isolated from QGB were described. Seven compounds were isolated and identified as picraquassioside D (1), quercussioside (2), (+)-lyoniresinol-9'α-O-β-d-xylopyranoside (3), (+)-catechin (4), (-)-epicatechin (5), procyanidin B-3 (6), and procyanidin B-4 (7). Compounds 5-7 showed potent anti-oxidative and anti-inflammatory activities. These compounds were further tested for their inhibition of the gene expression of the inflammatory cytokines. The three compounds 5-7 showed dose-dependent inhibitory activities on gene expression of COX-2 and IL-1β. In vivo, urolithiasis was induced more effectively in an animal model of acute urolithiasis by the administration of QGB extract. These results indicate the potential of compounds from QGB in the treatment of urolithiasis. |
| Databáze: | OpenAIRE |
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