Clinical and Biochemical Evaluation of Patients with Hirsutism
| Autor: | I. M. Holdaway, M. S. Croxson, P. A. Frengley, H. K. Ibbertson, A. Sheehan, A. Fraser, M. C. Evans, B. S. Knox, J. T. France, F. M. Graham, G. C. Liggins |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Hirsutism medicine.medical_specialty Adolescent medicine.drug_class Radioimmunoassay chemistry.chemical_compound Dehydroepiandrosterone sulfate Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine Photography medicine Humans Androstenedione Testosterone hirsutism biology Dehydroepiandrosterone Sulfate business.industry Virilization Obstetrics and Gynecology Dehydroepiandrosterone General Medicine Middle Aged Androgen medicine.disease Polycystic ovary 17-Ketosteroids Endocrinology chemistry Gonadotropins Pituitary biology.protein Female medicine.symptom business Hair Polycystic Ovary Syndrome |
| Zdroj: | The Australian and New Zealand Journal of Obstetrics and Gynaecology. 24:23-29 |
| ISSN: | 1479-828X 0004-8666 |
| DOI: | 10.1111/j.1479-828x.1984.tb03316.x |
| Popis: | Patients with moderate to severe hirsutism presenting over an 18-month period to an endocrine clinic were assessed by clinical evaluation and hormone measurements. Hair growth rate was estimated by a photographic technique and the severity of hirsutism graded using an objective scale. Of 43 patients, 9 had polycystic ovaries and the remainder were considered to have idiopathic hirsutism. The most severely affected group had significantly increased hair growth rates compared with less clinically affected subjects, and 47% of this group showed objective features of virilization. However, apart from a significantly higher 24-hr urine 17-ketosteroid excretion all other hormonal patterns were not significantly different between severely and mildly affected patients. Serum levels of testosterone (T), sex hormone-binding globulin (SHBG), free T (calculated from T and SHBG values), and androstenedione (A) were abnormal in 44%, 51%, 60% and 60% of patients respectively, whereas plasma levels of the specific adrenal androgen DHAS were increased in 40% of patients. There was an overlap between patients with elevated hormone levels, although isolated elevation of T, A or DHAS were seen in 9%, 19% and 3% of patients respectively. In 19% of patients all serum androgen measurements were normal. Gonadotrophin levels were significantly lower in the more severely affected group. Thus androgen levels in patients with idiopathic hirsutism or polycystic ovaries, show considerable overlap with measurements in normal subjects, and elevated plasma androgens may be of adrenal (DHAS) or combined adrenal/ovarian (T, A) origin. |
| Databáze: | OpenAIRE |
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