P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy
| Autor: | K. Khalil, Barbro Carlsson, Agnes E. Wold, Ingegerd Adlerberth, Catharina Svanborg, Lars Å. Hanson, Fehmida Jalil, Lotta Mellander |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Serotype
Epidemiology Fimbria medicine.disease_cause Bacterial Adhesion Pilus Microbiology Escherichia coli medicine Humans Typing Adhesins Escherichia coli biology Infant Newborn Rectum Infant O Antigens biochemical phenomena metabolism and nutrition biology.organism_classification Enterobacteriaceae Virology Bacterial adhesin Infectious Diseases Fimbriae Bacterial Bacteria Research Article |
| Zdroj: | Epidemiology and Infection. 121:599-608 |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose- resistant adherence to HT-29 cells, and expressed P fimbriae (P=0·0036) as well as other mannose-resistant adhesins (P=0·012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P=0·0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|