HTLV-1: Persistence and pathogenesis
| Autor: | Becca Asquith, Aileen G. Rowan, Lucy Cook, Marjet Elemans |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Leukemia
T-Cell Adolescent T cell Human leukocyte antigen Disease Biology Lymphoma T-Cell CD8+ T cells Pathogenesis Mathematical model Immune system Receptors KIR HLA Antigens immune system diseases In vivo Immunodominance Virology medicine Humans Antigens Viral Tumor Receptor Human T-lymphotropic virus 1 virus diseases HTLV-I Infections Immunity Innate Paraparesis Tropical Spastic KIR Killer Cells Natural CTL medicine.anatomical_structure HTLV-1 Immunology T-Lymphocytes Cytotoxic |
| Zdroj: | Virology. 435:131-140 |
| ISSN: | 0042-6822 |
| Popis: | ContentsIntroduction. . 131HTLV-1 pathogenesis 132HTLV-1 and disease. . . 132ATL 132HAM/TSP . . 132Determinants of proviral load 132Integration and clonal expansion . . 132CD8þ T cell lysis 133The immune response to HTLV-1. . . 133Determinants of protective immunity 133Immunodominance 134‘‘Innate’’ receptors enhance the HLA class I-restricted response 135Persistence in the face of a strong immune response 136Immunogenicity of HTLV-I-infected cells 136Slow clearance of Tax-expressing cells in vivo 137Concluding remarks 137Is HBZ a viable target for HTLV-I vaccine design? 137Why is CTL killing low in vivo? 137How do KIRs affect the outcome of HTLV-1 infection? . . 137References . . . 137 |
| Databáze: | OpenAIRE |
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