Cell cycle regulation in Trypanosoma brucei
| Autor: | Hammarton, Tansy C |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cell division
Cell Review Signal transduction S Phase RNA interference Trypanosoma brucei Rb retinoblastoma CDK cyclin-dependent kinase 0303 health sciences 030302 biochemistry & molecular biology PCF procyclic form Cell cycle Cyclin-Dependent Kinases Cell biology MEN mitotic exit network medicine.anatomical_structure RNAi RNA interference K kinetoplast BSF bloodstream form kDNA kinetoplast deoxyribose nucleic acid RNA Interference Cell Division G2 Phase Trypanosoma brucei brucei Mitosis Biology FEAR Cdc14 early anaphase release network 03 medical and health sciences FAZ flagellum attachment zone Cyclin-dependent kinase parasitic diseases medicine Animals Molecular Biology 030304 developmental biology Cytokinesis Trypanosomatid N nucleus G1 Phase CRK cdc2-related kinase biology.organism_classification Phosphoric Monoester Hydrolases BB basal body APC anaphase promoting complex biology.protein Parasitology VSG variant surface glycoprotein IFT intraflagellar transport MAPK mitogen-activated protein kinase |
| Zdroj: | Molecular and Biochemical Parasitology |
| ISSN: | 0166-6851 |
| DOI: | 10.1016/j.molbiopara.2007.01.017 |
| Popis: | Cell division is regulated by intricate and interconnected signal transduction pathways that precisely coordinate, in time and space, the complex series of events involved in replicating and segregating the component parts of the cell. In Trypanosoma brucei, considerable progress has been made over recent years in identifying molecular regulators of the cell cycle and elucidating their functions, although many regulators undoubtedly remain to be identified, and there is still a long way to go with respect to determining signal transduction pathways. However, it is clear that cell cycle regulation in T. brucei is unusual in many respects. Analyses of trypanosome orthologues of conserved eukaryotic cell cycle regulators have demonstrated divergence of their function in the parasite, and a number of other key regulators are missing from T. brucei. Cell cycle regulation differs in different parasite life cycle stages, and T. brucei appears to use different checkpoint control strategies compared to model eukaryotes. It is therefore probable that T. brucei has evolved novel pathways to control its cell cycle. |
| Databáze: | OpenAIRE |
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