Minimally invasive esophagectomy versus open esophagectomy for esophageal cancer: a meta-analysis
| Autor: | Weidong Hu, Lu Lv, Xiaoxuan Wei, Yanchen Ren |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
genetic structures business.industry medicine.medical_treatment General surgery thoracoscopic esophagectomy 030230 surgery Esophageal cancer medicine.disease laparoscopic esophagectomy OncoTargets and Therapy 03 medical and health sciences 0302 clinical medicine Oncology Esophagectomy 030220 oncology & carcinogenesis Meta-analysis Invasive esophagectomy medicine postoperative prognosis Thoracoscopic esophagectomy Pharmacology (medical) business Original Research |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Lu Lv, Weidong Hu, Yanchen Ren, Xiaoxuan Wei Hubei Key Laboratory of Tumor Biological Behaviors, Department of Thoracic Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China Background and objectives: The safety and effectiveness of minimally invasive esophagectomy (MIE) in comparison with the open esophagectomy (OE) remain uncertain in esophageal cancer treatment. The purpose of this meta-analysis is to compare the outcomes of the two surgical modalities. Methods: Searches were conducted in MEDLINE, EMBASE, andClinicalTrials.govwith the following index words: “esophageal cancer”, “VATS”, “MIE”, “thoracoscopic esophagectomy”, and “open esophagectomy” for relative studies that compared the effects between MIE and OE. Random-effect models were used, and heterogeneity was assessed. Results: A total of 20 studies were included in the analysis, consisting of four randomized controlled trials and 16 prospective studies. MIE has reduced operative blood loss (P=0.0009) but increased operation time (P=0.009) in comparison with OE. Patients get less respiratory complications (risk ratio =0.74, 95% CI =0.58–0.94, P=0.01) and better overall survival (hazard ratio =0.54, 95% CI =0.42–0.70, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|