Primary cutaneous malignant perivascular epithelioid cell tumor: Case of a rare tumor with review of the literature

Autor:	Scott C. Bresler, Tyler D Menge, Douglas R. Fullen, Leela M Hamp, Daniel W Cole, Sruthi Renati, Rajiv M. Patel
Rok vydání:	2021
Předmět:	Adult Pathology medicine.medical_specialty Skin Neoplasms Histology Perivascular Epithelioid Cell Neoplasms Biopsy Dermatology Perivascular Epithelioid Cell Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Atypia Humans Medicine Neoplasm Skin integumentary system biology business.industry CD68 Mesenchymal stem cell Margins of Excision medicine.disease Combined Modality Therapy Immunohistochemistry Actins Caldesmon Treatment Outcome 030220 oncology & carcinogenesis biology.protein Calmodulin-Binding Proteins Female Radiotherapy Adjuvant Dermatopathology business Follow-Up Studies
Zdroj:	Journal of Cutaneous Pathology. 48:1088-1093
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.14034
Popis:	Perivascular epithelioid cell tumors (PEComas) are mesenchymal neoplasms with characteristic epithelioid or spindled cytomorphology that typically grow around blood vessels. These tumors are phenotypically and immunohistochemically distinct, expressing markers of both melanocytic and smooth muscle differentiation. Herein, we describe a case of histopathologically malignant cutaneous PEComa without metastatic spread, with review of the pertinent literature. Telescoping punch biopsy demonstrated an epithelioid neoplasm with marked atypia, hypercellularity, and increased mitotic activity. Immunohistochemical stains for HMB-45, NK1-C3, PGP9.5, MiTF, CD10, and CD68 were positive within tumor cells. In addition, there was diffuse expression of caldesmon and focal cytoplasmic staining for smooth muscle actin on the excision specimen. The patient underwent treatment with surgical excision with adjuvant radiation and surveillance computed tomography (CT). The patient remains free of recurrence or metastatic disease after 10 months of follow-up. To our knowledge, this is only the third reported case of a malignant cutaneous PEComa reported in the literature to date.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da198b401801a23252213f9fd8eedb9 https://doi.org/10.1111/cup.14034 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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