A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum
| Autor: | Esther van de Vosse, Jaap T. van Dissel, Leo G. Visser, Wendy F. van der Meide, Annelies van Wengen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Pathology medicine.medical_specialty 030106 microbiology Histoplasma Case Report Human leukocyte antigen Histoplasma capsulatum Peripheral blood mononuclear cell Histoplasmosis IFN-gamma 03 medical and health sciences Interferon-gamma Lymphadenitis medicine Humans Immunodeficiency IFN-γ Netherlands Autoantibodies biology business.industry Autoantibody General Medicine Cervical lymphadenitis medicine.disease biology.organism_classification HLA 030104 developmental biology Infectious Diseases Immunology Primary immunodeficiency Leukocytes Mononuclear Female business |
| Zdroj: | Infection, 45(6), 917-920 Infection |
| DOI: | 10.1007/s15010-017-1060-x |
| Popis: | Case presentation We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. Conclusion IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|