New method of screening for COVID-19 disease using sniffer dogs and scents from axillary sweat samples
| Autor: | Clothilde Lecoq-Julien, Georges Mjaess, Michele Saliba, Riad Sarkis, Nabil M Jabbour, Anthony Lichaa, Carlo Selman, Dominique Grandjean |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Axillary sweat Disease Sensitivity and Specificity Gastroenterology Asymptomatic 03 medical and health sciences Dogs 0302 clinical medicine Internal medicine Working Dogs Correspondence medicine Animals Humans AcademicSubjects/MED00860 030212 general & internal medicine Sweat 030304 developmental biology 0303 health sciences SARS-CoV-2 business.industry Public Health Environmental and Occupational Health COVID-19 General Medicine Odorants medicine.symptom business |
| Zdroj: | Journal of Public Health (Oxford, England) |
| ISSN: | 1741-3850 1741-3842 |
| DOI: | 10.1093/pubmed/fdab215 |
| Popis: | Background Early screening for COVID-19 is needed to limit the spread of the virus. The aim of this study is to test if the sniffer dogs can be successfully trained to identify subjects with COVID-19 for ‘proof of concept’ and ‘non-inferiority’ against PCR. We are calling this method, Dognosis (DN). Methods Four hundred and fifty-nine subjects were included, 256 (Group ‘P’) were known cases of COVID-19 (PCR positive, some with and some without symptoms) and 203 (Group ‘C’) were PCR negative and asymptomatic (control). Samples were obtained from the axillary sweat of each subject in a masked fashion. Two dogs trained to detect specific Volatile Organic Compounds for COVID-19 detection were used to test each sample. Results [DN] turned out positive (+) in all the cases that were PCR positive (100% sensitivity). On the other hand, [DN] turned positive (+) in an average of 12.5 cases (6.2%) that were initially PCR negative (apparent specificity of 93.8%). When the PCR was repeated, true specificity was 97.2%. These parameters varied in subgroups from 100% sensitivity and 99% specificity in symptomatic patients to 100% sensitivity and 93% specificity in asymptomatic patients. Conclusion DN method shows high sensitivity and specificity in screening COVID-19 patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|