Risk factors for active tuberculosis in 938 QuantiFERON-positive schoolchildren in Mongolia: a community-based cross-sectional study
| Autor: | Erdenetuya Ganbaatar, Adrian R. Martineau, Gantsetseg Garmaa, Davaasambuu Ganmaa, Sumiya Erdenebaatar, Delgerekh Baigal, Munkhzul Baatar, Uyanga Buyanjargal, Polyna Khudyakov, Yanjindulam Purevsuren, Buyankhishig Burneebaatar, Nomin Enkhamgalan, Enkhtamir Purevdorj, Batbayar Ochirbat |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty QuantiFERON®-TB gold Tuberculosis Adolescent Cross-sectional study 030106 microbiology Disease lcsh:Infectious and parasitic diseases QuantiFERON 03 medical and health sciences 0302 clinical medicine Latent Tuberculosis Surveys and Questionnaires Internal medicine Odds Ratio medicine Vitamin D and neurology Humans Mass Screening lcsh:RC109-216 030212 general & internal medicine Vitamin D Child Tuberculosis Pulmonary Children 2. Zero hunger Hematologic Tests Latent tuberculosis business.industry Smoking Confounding Mongolia medicine.disease Mycobacterium bovis 3. Good health Cross-Sectional Studies Infectious Diseases Risk factors Relative risk Disease Progression Female business Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background There is controversy regarding the relative influence of ‘exogenous’ versus ‘endogenous’ factors on the risk of progression from latent tuberculosis infection to active tuberculosis (TB) disease in children. Methods We conducted a cross-sectional analysis to identify risk factors for active tuberculosis in QuantiFERON®-TB Gold (QFT-G)-positive children aged 6–13 years attending 18 schools in Ulaanbaatar, Mongolia. Children underwent clinical and radiological screening for active tuberculosis, and data relating to potential risk factors for disease progression were collected by questionnaire and determination of serum 25-hydroxyvitamin D (25[OH]D) concentrations. Risk ratios were calculated using generalized estimating equations with adjustment for potential confounders. Results 129/938 (13.8%) QFT-positive children were diagnosed with active tuberculosis. Risk of active tuberculosis was independently associated with household exposure to pulmonary TB (adjusted risk ratio [aRR] 2.40, 95% CI 1.74 to 3.30, P |
| Databáze: | OpenAIRE |
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