Study of bioaccumulation of dalteparin at a therapeutic dose in patients with renal insufficiency
| Autor: | D. Brodmann, Walter A. Wuillemin, A. G. Fischer, Y. Odermatt, Pirmin Schmid |
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| Rok vydání: | 2009 |
| Předmět: |
Dalteparin
Male medicine.medical_specialty Metabolic Clearance Rate medicine.drug_class Injections Subcutaneous Urology Low molecular weight heparin Renal function Therapeutic index Pharmacokinetics Interquartile range medicine Humans Prospective Studies Dosing Prospective cohort study Aged Aged 80 and over Inpatients business.industry Anticoagulants Hematology Middle Aged Surgery Kidney Failure Chronic Female business Factor Xa Inhibitors Glomerular Filtration Rate Cohort study |
| Zdroj: | Journal of Thrombosis and Haemostasis. 7:1629-1632 |
| ISSN: | 1538-7836 |
| DOI: | 10.1111/j.1538-7836.2009.03556.x |
| Popis: | Summary. Background: Low-molecular-weight heparins (LMWH) are effective, safe and convenient for anticoagulation. Their use is limited in patients with renal insufficiency (RI) because of bioaccumulation. Objectives: Evaluate pharmacokinetic data of dalteparin at a therapeutic dose in patients with RI. Patients and methods: Prospective observational cohort study. Inpatients were included into three groups according to glomerular filtration rate (GFR): A ≥ 60, B 30–59, C |
| Databáze: | OpenAIRE |
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