A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
| Autor: | Andy Lin, Sangtae Ahn, Christopher C. Park, Desmond J. Smith, Richard T. Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Male Radiation Hybrid Mapping Genotype Genome Human Systems biology Gene regulatory network Method Computational biology Biology Genome Gene interaction Protein Interaction Mapping Humans Radiation hybrid mapping Human genome Female Gene Regulatory Networks Centrality Genetics (clinical) Biological network Genome-Wide Association Study |
| Popis: | Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein–protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell. |
| Databáze: | OpenAIRE |
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