Homocysteine Levels and Echocardiographic Findings in Obstructive Sleep Apnea Syndrome
| Autor: | Fehime Benli Aksungar, Akın Cem Soylu, Osman Bektaş, Ender Levent, Nesrin Sarıman |
|---|---|
| Přispěvatelé: | Maltepe Üniversitesi |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Heart Diseases Homocysteine Homocysteine levels urologic and male genital diseases C-reactive protein chemistry.chemical_compound medicine Humans Aged Ultrasonography Oxygen saturation (medicine) Sleep Apnea Obstructive biology business.industry Respiratory disease Middle Aged Airway obstruction medicine.disease Sleep in non-human animals Respiratory Function Tests respiratory tract diseases Obstructive sleep apnea Obstructive sleep apnea syndrome chemistry Echocardiography Anesthesia Disease Progression biology.protein Female business |
| Zdroj: | Respiration. 79:38-45 |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000210429 |
| Popis: | WOS: 000271536000007 PubMed ID: 19339768 Background: The obstructive sleep apnea syndrome (OSAS) is characterized by repeated upper airway obstruction during sleep together with decreases in oxygen saturation leading to a series of pathological events, primarily in the cardiovascular system. Elevated plasma homocysteine levels have recently been considered as an independent risk factor for vascular disease, and increased levels are attributed to cardiovascular diseases. Objectives: We aimed to investigate the possible relationship between homocysteine levels and echocardiographic findings in OSAS patients at different stages of disease. Methods: Thirty-eight patients (23 males and 15 females) with polysomnographically verified OSAS (mean age, 49 +/- 12 years, range 27-74) and a mean body mass index of 31.27 +/- 5.24 kg/m(2) (range 22.60-47.90) were prospectively studied. Plasma levels of homocysteine, cholesterols, triglycerides, vitamin B(12) and high-sensitive C-reactive protein (hsCRP), as well as echocardiographic and lung function parameters were assessed. Results: Homocysteine levels were elevated in all OSAS groups and were statistically significantly different between the mild and moderate/severe groups. Significant differences were present between the variables nocturnal oxygen desaturation (NOD), respiratory arousal and light sleep among the mild and moderate/severe groups. We found a significant positive correlation between homocysteine levels and NOD duration, and hsCRP levels were positively correlated with the apnea-hypopnea index and NOD duration. Conclusions: In all OSAS groups, homocysteine levels were elevated regardless of the presence of cardiac dysfunction. Echocardiographic abnormalities were primarily left-ventricular (LV) hypertrophy and LV diastolic dysfunction and could be observed in all OSAS severity groups. Copyright (C) 2009 S. Karger AG, Basel |
| Databáze: | OpenAIRE |
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