Heteroatom-Guided, Palladium-Catalyzed Regioselective C–H Functionalization in the Synthesis of 3-Arylquinolines

Autor:	Riki Das, Amit Adhikary, Virendra Kumar Tiwari, Govind Pawar, Manmohan Kapur
Rok vydání:	2013
Předmět:	Chemistry Aryl Organic Chemistry Heteroatom Aromatization Regioselectivity chemistry.chemical_element Biochemistry Catalysis Transmetalation chemistry.chemical_compound Yield (chemistry) Organic chemistry Physical and Theoretical Chemistry Palladium
Zdroj:	Organic Letters. 15:3310-3313
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol401349a
Popis:	A new approach for the regioselective functionalization of the C-3-position of quinolines is described. The method utilizes heteroatom guided regioselective C-3 palladation followed by arylation via transmetalation with aryl boronic acids to yield 3-aryl-N-acyl-1,2-dihydroquinolines. In a one-pot sequence, N-deacylation followed by aromatization leads to important 3-arylquinolines in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d990f86c5867884e8813e05e49e8654 https://doi.org/10.1021/ol401349a Zobrazit plný text záznamu