Developing a framework regarding a complex risk based methodology in the evaluation of hazards associated with medicinal products sourced via the internet
| Autor: | András Fittler, Róbert György Vida, Eszter Jáhn, Sára Merczel |
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| Rok vydání: | 2020 |
| Předmět: |
media_common.quotation_subject
Specific risk Pharmaceutical Science Pharmacy Test purchase 030226 pharmacology & pharmacy 03 medical and health sciences Patient safety 0302 clinical medicine Eye drops Quality (business) 030212 general & internal medicine Risk assessment media_common Pharmacology Descriptive statistics business.industry lcsh:RM1-950 Internet pharmacy Product (business) Counterfeit medicine lcsh:Therapeutics. Pharmacology Risk analysis (engineering) Original Article The Internet Business Online medicines |
| Zdroj: | Saudi Pharmaceutical Journal : SPJ Saudi Pharmaceutical Journal, Vol 28, Iss 12, Pp 1733-1742 (2020) |
| ISSN: | 1319-0164 |
| Popis: | Today, the increasing number of illicit internet pharmacies is a global phenomenon, however, the size of the online pharmaceutical market is still relatively unknown and the dubious quality of products is questionable and warrants investigation. Descriptive data from this black market channel are derived from studies analyzing the online availability of different medications procured over the internet and their methodology is quite heterogeneous. Our aim was to develop a comprehensive and specific risk assessment for selecting high patient safety risk medications from the online pharmaceutical market. A rapid tool was developed based upon the two quality and safety standard resolutions in pharmaceutical practice, published by the European Directorate for the Quality of Medicines, and was illustrated on eye drops. We developed five dimensions in support of the risk assessment including intrinsic, extrinsic and potential risks of counterfeiting. The five criteria were integrated in a comprehensively weighted risk-scoring format. The probability of procuring the product from the internet was also assessed based on the number of relevant links within the first twenty search engine results and the cost of the products. With the application of the tool a dorzolamide & timolol combination eye drop represented the highest overall patient safety risk score. In consideration of our literature review of the past 20 years, there is no current, standardized methodology to effectively identify pharmaceutical products associated with high patient safety risks. Notably, the fully comprehensive analysis of the internet pharmaceutical market and the test purchase of all online available medicines is unrealistic. Therefore, we developed a method to aid online surveillance researches and targeted international organizational led joint actions against the uncontrolled sale of falsified and substandard medications (e.g.: Operation Pangea). |
| Databáze: | OpenAIRE |
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