In vitro and in vivo biological evaluation of newly synthesized multi-target 20(R)-panaxadiol derivatives for treating Alzheimer's disease

Autor:	Lei Pang, Jin Li, Zheng Liu, Yin-Sheng Quan, He Huan Sui, Yi Jia, Fener Chen, Jung Joon Lee, Peng Liu, Zhe-Shan Quan, Qing-Kun Shen, Hong-Yan Guo
Rok vydání:	2022
Předmět:	Pharmacology Mice Amyloid beta-Peptides Neuroprotective Agents Alzheimer Disease Drug Design Organic Chemistry Drug Discovery Acetylcholinesterase Animals Donepezil General Medicine Cholinesterase Inhibitors
Zdroj:	European journal of medicinal chemistry. 244
ISSN:	1768-3254
Popis:	An extensive study was performed to discover a series of novel 20(R)-panaxadiol derivatives with various substituents at the 3-OH position as nontoxic, brain-permeable, multi-target leads for treating Alzheimer's disease. In vitro analysis revealed that a compound bearing benzyl-substituted carbamate, which we denoted compound 14a, exhibited the most potent neuroprotective activity, with an EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d973e33c2a5af75808baaf46a333e45 https://pubmed.ncbi.nlm.nih.gov/36306540 Zobrazit plný text záznamu Full Text from ScienceDirect