Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand
| Autor: | Nina Brandstack, Anastasia Shulga, Erika Kirveskari, Linda Kuusela, Sarianna Savolainen, Aleksandra Tolmacheva, Jyrki P. Mäkelä, Pantelis Lioumis, Aarne Ylinen |
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| Přispěvatelé: | HUS Medical Imaging Center, BioMag Laboratory, Department of Neurosciences, Kliinisen neurofysiologian yksikkö, Department of Physics, Clinicum, Department of Diagnostics and Therapeutics, University of Helsinki, HUS Neurocenter, Neurologian yksikkö |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment Peripheral nerve stimulation Stimulation 3124 Neurology and psychiatry 0302 clinical medicine SPINAL-CORD-INJURY Spinal cord injury Stroke Tetraplegia INDUCTION Motor Cortex RECOVERY MUSCLE Middle Aged Transcranial Magnetic Stimulation 3. Good health medicine.anatomical_structure Treatment Outcome Female LTP Psychology STROKE TIMING-DEPENDENT PLASTICITY Adult paired associative stimulation medicine.medical_specialty CORTEX Electric Stimulation Therapy Motor Activity Quadriplegia 03 medical and health sciences Paired associative stimulation Physical medicine and rehabilitation medicine Humans Muscle Strength Muscle Skeletal Spinal Cord Injuries Aged peripheral electrical stimulation 3112 Neurosciences ELECTRICAL-STIMULATION Original Articles medicine.disease Spinal cord Evoked Potentials Motor Hand spinal cord injury Transcranial magnetic stimulation 030104 developmental biology plasticity Physical therapy Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma |
| ISSN: | 1557-9042 |
| Popis: | A large proportion of spinal cord injuries (SCI) are incomplete. Even in clinically complete injuries, silent non-functional connections can be present. Therapeutic approaches that can strengthen transmission in weak neural connections to improve motor performance are needed. Our aim was to determine whether long-term delivery of paired associative stimulation (PAS, a combination of transcranial magnetic stimulation [TMS] with peripheral nerve stimulation [PNS]) can enhance motor output in the hands of patients with chronic traumatic tetraplegia, and to compare this technique with long-term PNS. Five patients (4 males; age 38-68, mean 48) with no contraindications to TMS received 4 weeks (16 sessions) of stimulation. PAS was given to one hand and PNS combined with sham TMS to the other hand. Patients were blinded to the treatment. Hands were selected randomly. The patients were evaluated by a physiotherapist blinded to the treatment. The follow-up period was 1 month. Patients were evaluated with Daniels and Worthingham's Muscle Testing (0-5 scale) before the first stimulation session, after the last stimulation session, and 1 month after the last stimulation session. One month after the last stimulation session, the improvement in the PAS-treated hand was 1.02 +/- 0.17 points (p |
| Databáze: | OpenAIRE |
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