Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors

Autor: Patrick Schöffski, Vanessa Vanspauwen, Thomas Van Looy, Anna Quattrone, Agnieszka Wozniak, Piotr Rutkowski, Giuseppe Floris, Raf Sciot, Barbara Dewaele, Maria Debiec-Rychter
Rok vydání: 2014
Předmět:
Male
MAPK/ERK pathway
Small interfering RNA
DNA Mutational Analysis
Loss of Heterozygosity
Piperazines
Tensin
Treatment Failure
Phosphorylation
Child
In Situ Hybridization
Fluorescence
Aged
80 and over
TOR Serine-Threonine Kinases
Middle Aged
Immunohistochemistry
Benzamides
Imatinib Mesylate
Female
RNA Interference
Mitogen-Activated Protein Kinases
Signal Transduction
medicine.drug
Adult
Gastrointestinal Stromal Tumors
Antineoplastic Agents
Biology
Transfection
Pathology and Forensic Medicine
Young Adult
Cell Line
Tumor
Biomarkers
Tumor
medicine
Humans
PTEN
Protein Kinase Inhibitors
neoplasms
Protein kinase B
PI3K/AKT/mTOR pathway
Aged
PTEN Phosphohydrolase
Imatinib
Enzyme Activation
Pyrimidines
Imatinib mesylate
Drug Resistance
Neoplasm
Mutation
Cancer research
biology.protein
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Zdroj: Modern Pathology. 27:1510-1520
ISSN: 0893-3952
Popis: Insufficiency of phosphatase and tensin homolog (PTEN) occurs in numerous tumor types and has been implicated as a resistance mechanism to receptor tyrosine kinase-targeted therapies in human cancer. In this study, we have performed a comprehensive molecular and immunohistochemical characterization of PTEN in 58 imatinib-naive and 54 imatinib-treated gastrointestinal stromal tumors (GISTs). The findings were correlated with clinicopathological data. At the genomic level, PTEN was affected mainly by mono-allelic loss, which was significantly less frequent in imatinib-naive vs imatinib-resistant tumors (9% vs 39%, P
Databáze: OpenAIRE
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