Serum Concentrations of BNP and ANP in Patients with Thyrotoxicosis
| Autor: | Keiko Kato, Hitomi Murakami, Toshio Tsushima, Kazue Takano, Osamu Isozaki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Graves' disease Renin-Angiotensin System Endocrinology Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain Renin Natriuretic peptide medicine Humans Euthyroid cardiovascular diseases Aldosterone Heart Failure business.industry Osmolar Concentration Thyroid Atrial fibrillation Middle Aged medicine.disease Graves Disease Thyrotoxicosis medicine.anatomical_structure Case-Control Studies Heart failure cardiovascular system Cardiology Female Thyroid function business human activities Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Endocrine Journal. 56:17-27 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.k08e-145 |
| Popis: | Serum BNP (brain naturiuretic peptide) and ANP (atrial natriuretic peptide) levels are reportedly elevated in patients with thyrotoxicosis. The increases may not be due to thyrotoxicosis itself but to secondary cardiovascular changes such as chronic heart failure (HF) or atrial fibrillation (AF) which frequently accompany thyrotoxicosis. We measured serum ANP and BNP levels in 130 patients with thyrotoxicosis and correlated them with HF severity and thyroid function. Thirty-seven normal subjects served as controls. Serum BNP levels in thyrotoxic patients were significantly higher than those in control subjects and significantly correlated with serum free T4, free T3 and ANP levels. In untreated Graves' disease serum BNP level was significantly elevated in patients with HF or AF. Multiple regression analysis revealed that HF, free T4, female gender and AF are independent contributing factors to the elevated BNP level, and that these four factors contributed about 40%. On the other hand, HF and AF were contributing variables for ANP level but the overall contribution of these factors was only 10%. After normalization of thyroid function, serum BNP levels were normalized in 70.5% of Graves' patients. BNP level in euthyroid state was dependent on the presence of HF and the BNP value before therapy, but not on thyroid hormone levels or AF. These data suggest that the cardiovascular condition is the major factor responsible for the elevated serum BNP and ANP levels in thyrotoxic patients, while thyrotoxicosis itself is an independent but minor contributing factor. Thus, the determination of serum BNP levels in thyrotoxic patients is useful for monitoring cardiovascular conditions of HF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|