Circulating Oxytocin Is Genetically Determined and Associated With Obesity and Impaired Glucose Tolerance
| Autor: | Anke Tönjes, Michael Stumvoll, Markus Scholz, Katrin Horn, Mark Florian Joachim Weingarten, Peter Kovacs, Tobias Wohland |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Context (language use) Oxytocin Biochemistry Body Mass Index Impaired glucose tolerance chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Glucose Intolerance Humans Insulin Medicine Obesity Triglyceride business.industry Biochemistry (medical) Genetic Variation Glucose Tolerance Test Middle Aged medicine.disease chemistry Female business Body mass index hormones hormone substitutes and hormone antagonists Genome-Wide Association Study medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 104:5621-5632 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | ContextDespite the emerging evidence on the role of oxytocin (OXT) in metabolic diseases, there is a lack of well-powered studies addressing the relationship of circulating OXT with obesity and diabetes.Objectives and DesignHere, we measured OXT in a study cohort (n = 721; 396 women, 325 men; mean age ± SD, 47.7 ± 15.2 years) with subphenotypes related to obesity, including anthropometric traits such as body mass index [BMI (mean ± SD), 26.8 ± 4.6 kg/m2], waist-to-hip ratio (WHR; 0.88 ± 0.09), blood parameters (glucose, 5.32 ± 0.50 mmol/L; insulin, 5.3 ± 3.3 µU/mL), and oral glucose tolerance test to clarify the association with OXT. We also tested in a genome-wide association study (GWAS) whether the interindividual variation in OXT serum levels might be explained by genetic variation.ResultsThe OXT concentration was increased in subjects with elevated BMI and positively correlated with WHR, waist circumference, and triglyceride levels. The OXT concentration in subjects with BMI 30 kg/m2 (n = 137; 106.4 pg/mL, P = 8 × 10−6). OXT levels were also positively correlated with plasma glucose and insulin and were elevated in subjects with impaired glucose tolerance (P = 4.6 × 10−3). Heritability of OXT was estimated at 12.8%. In a GWAS, two hits in linkage disequilibrium close (19 kb) to the OXT reached genome-wide significant association (top-hit rs12625893, P = 3.1 × 10−8, explained variance 3%).ConclusionsOur data show that OXT is genetically affected by a variant near OXT and is associated with obesity and impaired glucose tolerance. |
| Databáze: | OpenAIRE |
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