Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder
| Autor: | Judith L. Rapoport, Gail F. Ritchie, Markus J.P. Kruesi, Ivan N. Mefford, Josephine Elia, Charles S. Gulotta, F. Xavier Castellanos, William Z. Potte |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Dextroamphetamine Motor Activity Impulsivity Methoxyhydroxyphenylglycol Norepinephrine chemistry.chemical_compound Double-Blind Method Dopamine Internal medicine medicine Humans Attention deficit hyperactivity disorder Attention Child Biological Psychiatry Neurotransmitter Agents 5-Hydroxyindoleacetic acid Homovanillic acid Homovanillic Acid Hydroxyindoleacetic Acid medicine.disease Aggression Psychiatry and Mental health Monoamine neurotransmitter Endocrinology chemistry Attention Deficit Disorder with Hyperactivity Impulsive Behavior Methylphenidate 3-Methoxy-4-hydroxyphenylglycol medicine.symptom Psychology medicine.drug |
| Zdroj: | Psychiatry Research. 52:305-316 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(94)90076-0 |
| Popis: | Cerebrospinal fluid (CSF), plasma, and urinary monoamine metabolites were determined for 29 boys, aged 6–12, with attention-deficit hyperactivity disorder (ADHD). Levels of CSF 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG), the metabolites of serotonin, dopamine, and norepinephrine, respectively, correlated significantly with behavioral measures of aggression and impulsivity/hyperactivity. However, these correlations were in the unexpected direction; for example, CSF 5-HIAA correlated positively with the Brown-Goodwin Lifetime History of Aggression Scale. HVA in CSF was positively correlated with several measures of hyperactivity. The replicability of these findings, as well as possible socioenvironmental effects, and the predictive value of CSF monoamines in prepubertal hyperactivity are the subjects of ongoing study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|