Electrophysiological actions of somatostatin on the atrioventricular junction in sinus rhythm and reentry tachycardia
| Autor: | S C Webb, Stephen R. Bloom, Dennis M. Krikler, T E Adrian, W G Hendry |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Tachycardia medicine.medical_specialty Refractory period Electrocardiography Heart Conduction System Internal medicine Heart rate medicine Humans Sinus rhythm cardiovascular diseases business.industry Reentry Middle Aged Atrioventricular node Electrophysiology medicine.anatomical_structure Somatostatin Verapamil Anesthesia Atrioventricular Node cardiovascular system Cardiology Female Wolff-Parkinson-White Syndrome medicine.symptom Cardiology and Cardiovascular Medicine business Research Article medicine.drug |
| Zdroj: | Heart. 56:236-241 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.56.3.236 |
| Popis: | Because somatostatin, a neuroregulatory peptide, is found in abundance in the atria and atrioventricular node, its electrophysiological and antiarrhythmic properties were compared with those of verapamil in ten patients with paroxysmal atrioventricular tachycardia. During sinus rhythm, intravenous somatostatin slowed the heart rate whereas verapamil increased it. Though both agents prolonged atrioventricular conduction time and refractoriness, verapamil was more potent. They were equally effective at terminating reentry atrioventricular tachycardia, restoring sinus rhythm in six of seven patients. Whereas verapamil consistently blocked conduction in the atrioventricular node, somatostatin usually induced ventricular extrasystoles at the time of conversion. Somatostatin may have physiological importance in the neurohumoral control of cardiac impulse formation and conduction. |
| Databáze: | OpenAIRE |
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