Does the β-Blocker Nebivolol Increase Coronary Flow Reserve?
| Autor: | Linda Abrecht, Peter Wenaweser, Francesco Vigorito, Otto M. Hess, Stephan Windecker, Stéphane Cook, Mario Togni, Bernhard Meier, Michael Billinger |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Vasodilator Agents Adrenergic beta-Antagonists Collateral Circulation Coronary Artery Disease Balloon Nebivolol Coronary artery disease Basal (phylogenetics) Internal medicine Angioplasty Heart rate Medicine Humans Infusions Intra-Arterial Pharmacology (medical) Benzopyrans Angioplasty Balloon Coronary Pharmacology business.industry Coronary flow reserve General Medicine Middle Aged medicine.disease Echocardiography Doppler Ethanolamines Cardiology Female Vascular Resistance Cardiology and Cardiovascular Medicine business Perfusion Blood Flow Velocity medicine.drug |
| Zdroj: | Togni, Mario; Vigorito, Francesco; Windecker, Stephan; Abrecht, Linda; Wenaweser, Peter; Cook, Stephane; Billinger, Michael; Meier, Bernhard; Hess, Otto M (2007). Does the beta-blocker nebivolol increase coronary flow reserve? Cardiovascular drugs and therapy, 21(2), pp. 99-108. Branford, Conn.: Kluwer Academic Publishers-Plenum Publishers 10.1007/s10557-006-0494-7 |
| Popis: | INTRODUCTION: Nebivolol, a highly selective beta1-adrenergic receptor-blocker, increases basal and stimulated endothelial nitric oxide (NO)-release. It is unknown, whether coronary perfusion is improved by the increase in NO availability. Therefore, we sought to evaluate the effect of nebivolol on coronary flow reserve (CFR) and collateral flow. METHODS: Doppler-flow wire derived coronary flow velocity measurements were obtained in ten controls and eight patients with coronary artery disease (CAD) at rest and after intracoronary nebivolol. CFR was defined as maximal flow during adenosine-induced hyperemia divided by resting flow. In the CAD group, collateral flow was determined after dilatation of a flow-limiting coronary stenosis. Collateral flow index (CFI) was defined as the ratio of flow velocity during balloon inflation divided by resting flow. RESULTS: CFR at rest was 3.0+/-0.6 in controls and 2.1+/-0.4 in CAD patients. After intracoronary doses of 0.1, 0.25, and 0.5 mg nebivolol, CFR increased to 3.4+/-0.7, 3.9+/-0.9, and 4.0+/-0.1 (p |
| Databáze: | OpenAIRE |
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