CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
| Autor: | Yin-Shiou Lin, Maria Planta, Alicia Bell, Steven F. Ziegler, Robert B. Jackson, Marybeth Daucher, Sarah Kern, Mary McGlaughlin, Audrey Kinter, Anthony S. Fauci, Margaret Hennessey |
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| Rok vydání: | 2004 |
| Předmět: |
proliferation
T cell Immunology chemical and pharmacologic phenomena Biology Article 03 medical and health sciences Interleukin 21 0302 clinical medicine FoxP3 cytokine medicine Immunology and Allergy Cytotoxic T cell human IL-2 receptor Antigen-presenting cell 030304 developmental biology 0303 health sciences FOXP3 suppression Acquired immune system 3. Good health medicine.anatomical_structure CTLA-4 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20032069 |
| Popis: | Human immunodeficiency virus (HIV) disease is associated with loss of CD4+ T cells, chronic immune activation, and progressive immune dysfunction. HIV-specific responses, particularly those of CD4+ T cells, become impaired early after infection, before the loss of responses directed against other antigens; the basis for this diminution has not been elucidated fully. The potential role of CD25+CD4+ regulatory T cells (T reg cells), previously shown to inhibit immune responses directed against numerous pathogens, as suppressors of HIV-specific T cell responses was investigated. In the majority of healthy HIV-infected individuals, CD25+CD4+ T cells significantly suppressed cellular proliferation and cytokine production by CD4+ and CD8+ T cells in response to HIV antigens/peptides in vitro; these effects were cell contact dependent and IL-10 and TGF-β independent. Individuals with strong HIV-specific CD25+ T reg cell function in vitro had significantly lower levels of plasma viremia and higher CD4+: CD8+ T cell ratios than did those individuals in whom this activity could not be detected. These in vitro data suggest that CD25+CD4+ T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease. |
| Databáze: | OpenAIRE |
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