The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
| Autor: | Reza Ranuh, Alpha Fardah Atthiyah, Badriul Hegar, Subianto Marto Sudarmo, Muzal Kadim, Ninung Rose Diana, Christy Manoppo, Yvan Vandenplas, Ahmad Suryawan, Zakiudin Munasir, Ariani Dewi Widodo, Ray Wagiu Basrowi, Supriatmo, Yulianti Wibowo |
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| Přispěvatelé: | Clinical sciences, Growth and Development, Pediatrics |
| Rok vydání: | 2018 |
| Předmět: |
Lacto-N-neotetraose
Physiology Review Article Breast feeding Breast milk Oligosaccharide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system 2'-Fucosyllactose fluids and secretions 030225 pediatrics Medicine Lactose health care economics and organizations Hepatology business.industry Human milk Gastroenterology Infant Infant nutrition chemistry Infant formula Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology business 2′-fucosyllactose |
| Zdroj: | Pediatric Gastroenterology, Hepatology & Nutrition |
| ISSN: | 2234-8646 |
| Popis: | Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition. |
| Databáze: | OpenAIRE |
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