Recent progress in biomedical applications of RGD-based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review
| Autor: | Marzieh Baneshi, Ali Jabari Arabzadeh, Hassan Bardania, Saman Hosseinkhani, Jalil Mehrzad, Reza Mahmoudi, Mohammad Ali Akrami, Mohsen Alipour |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
0206 medical engineering Integrin Biomedical Engineering Biomedical Technology Biocompatible Materials 02 engineering and technology Bone tissue Ligands Theranostic Nanomedicine Biomaterials Neovascularization Drug Delivery Systems Tissue engineering Neoplasms medicine Animals Humans Receptor Clinical Trials as Topic biology Tissue Engineering Regeneration (biology) Metals and Alloys Gene Transfer Techniques Biomaterial 021001 nanoscience & nanotechnology 020601 biomedical engineering medicine.anatomical_structure Drug delivery Ceramics and Composites Cancer research biology.protein medicine.symptom 0210 nano-technology Oligopeptides |
| Zdroj: | Journal of biomedical materials research. Part AREFERENCES. 108(4) |
| ISSN: | 1552-4965 |
| Popis: | Arginine-glycine-aspartic acid (RGD) peptide family is known as the most prominent ligand for extracellular domain of integrin receptors. Specific expression of these receptors in various tissue of human body and tight association of their expression profile with various pathophysiological conditions made these receptors a suitable targeting candidate for several disease diagnosis and treatment as well as regeneration of various organs. For these reasons, various forms of RGD-based integrins ligands have been greatly used in biomedical studies. Here, we summarized the last decade application progress of RGD for cancer theranostics, control of inflammation, thrombosis inhibition and critically discussed the effect of RGD peptides structure and sequence on the efficacy of gene/drug delivery systems in preclinical studies. Furthermore, we will show recent advances in application of RGD functionalized biomaterials for various tissue regenerations including cornea repair, artificial neovascularization and bone tissue regeneration. Finally, we analyzed clinically translatability of RGD peptides, considering examples of integrin ligands in clinical trials. In conclusion, prospects on using RGD peptide for precise drug delivery and biomaterial engineering are well discussed. |
| Databáze: | OpenAIRE |
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