Expression of Thrombospondin-1 in Cancer: A Role in Tumor Progression
| Autor: | George P. Tuszynski, Xiao-hua Qian |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Platelets
CD36 Antigens endocrine system Angiogenesis Extracellular matrix component Neovascularization Physiologic Biology General Biochemistry Genetics and Molecular Biology Extracellular matrix immune system diseases Neoplasms Thrombospondin 1 Tumor Cells Cultured medicine Humans Thrombospondins Extracellular Matrix Proteins Membrane Glycoproteins Neovascularization Pathologic Cell adhesion molecule virus diseases Cancer Blood Proteins medicine.disease Cell biology Tumor progression Cell Adhesion Molecules |
| Zdroj: | Experimental Biology and Medicine. 212:199-207 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Thrombospondin-1 (TSP-1), a trimeric high molecular weight glycoprotein, is one of the major secreted proteins of human platelets and an extracellular matrix component of a variety of cells including vascular endothelial cells and tumor cells. TSP-1 has been shown to be highly expressed in human malignant tissues and present in higher than normal levels in the plasma of cancer patients. TSP-1 has also been shown to promote hematogenous tumor spread, tumor cell adhesion and invasion, and angiogenesis. Overall these studies provide compelling evidence for the conclusion that TSP-1 plays an important role in tumor progression. |
| Databáze: | OpenAIRE |
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