Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster
| Autor: | Santiago Perez Lloret, Ana I. Esquifino, Patricia O. Castrillón, Rodolfo A. Cutrera, Daniel P. Cardinali, Veronica Boggio, Patricia Riccio |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Circadian clock Antineoplastic Agents Motor Activity Interferon-gamma Cellular and Molecular Neuroscience Developmental Neuroscience Cricetinae Internal medicine medicine Animals Interferon gamma Circadian rhythm Receptor Injections Intraventricular Behavior Animal Mesocricetus biology Chemistry Suprachiasmatic nucleus biology.organism_classification Circadian Rhythm Endocrinology Neurology Microinjections Suprachiasmatic Nucleus Golden hamster medicine.drug |
| Zdroj: | Neurosignals. 12:89-94 |
| ISSN: | 1424-8638 1424-862X |
| DOI: | 10.1159/000071818 |
| Popis: | The present study was undertaken to examine whether the intracerebroventricular (i.c.v.) administration of interferon (IFN)-gamma could modify 24-hour wheel running locomotor activity in the golden hamster. Hamsters implanted with a cannula in the third ventricle received a single i.c.v. injection of 1 microl of murine recombinant IFN-gamma (40 IU/microl) or its vehicle (saline) at ZT 6 or ZT 18 (with ZT 12 defined arbitrarily as the time of lights off) and their activities were monitored during 24 h. The i.c.v. administration of IFN-gamma at ZT 6 produced a significant phase advance in acrophase of rhythm, an effect not seen at ZT 18. Also, IFN-gamma depressed mesor value significantly, the effect was seen at both times. These results clearly showed that the circadian clock could be modified by IFN-gamma microinjections. One explanation could be the presence of IFN-gamma receptor in the rat suprachiasmatic nucleus, supporting a direct effect on the central oscillator. However, another hypothesis could not be ruled out. |
| Databáze: | OpenAIRE |
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