Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia
| Autor: | John F. Keaney, Joseph Galvin, Ronan Conlon, Usama Boles, Santhosh David, Edward Keelan, Gábor Széplaki, Richard Tanner |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Chest pain QT interval 03 medical and health sciences 0302 clinical medicine Ectasia Internal medicine medicine In patient cardiovascular diseases 030212 general & internal medicine QTc dispersions P wave dispersion business.industry Coronary artery ectasia medicine.disease medicine.anatomical_structure Increased risk P-wave dispersions Tp-Te/QT ratio Cardiology Original Article Tp-Te interval medicine.symptom Cardiology and Cardiovascular Medicine business Arrhythmia Artery |
| Zdroj: | Cardiology Research |
| ISSN: | 1923-2837 1923-2829 |
| DOI: | 10.14740/cr631w |
| Popis: | Background: Coronary artery ectasia (CAE) is defined as a diffuse dilatation of the diameter of the ectatic segment of the coronary artery, 1.5 times greater than that of the adjacent segment. The Tp-Te interval, P-wave and QTc dispersions are relatively new electrocardiographic markers associated with an increased risk of developing arrhythmias. Despite CAE increasing in prevalence in recent years, there is a sparsity of data available about its arrhythmogenic effect. The aim of the study was to evaluate QTc, P-wave dispersion and Tp-Te and Tp-Te/QT ratio in patients with CAE. Methods: A retrospective comparative study was designed for consecutive age- and sex-matched patients. Twenty patients with isolated CAE (group 1) and 20 control subjects (group 2), with normal coronary arteries, were included. All patients presented with chest pain and coronary angiogram was indicated. Outcome measures included Tp-Te interval, Tp-Te/QT ratio, QTc dispersion and P-wave dispersion. Measurement of electrocardiogram (ECG) parameters was conducted using standardized digital online software. Descriptive and inferential statistics were performed. Results: Mean Tp-Te (95.5 ± 9.01 ms) and Tp-Te/QT ratio (0.22 ± 0.02) were significantly prolonged in CAE group (Tp-Te: 84 ± 5.62 ms, P = 0.00009; Tp-Te/QT ratio: 0.20 ± 0.01, P = 0.00004). In addition, QTc (31.2 ± 3.71 ms) and P-wave dispersion (31.9 ± 5.46 ms) were significantly increased in comparison to the control group (QTc: 27.6 ± 2.82 ms, P = 0.00532 and 20 ± 3.77 ms, P = 0.00003 respectively). However, there was no difference in ventricular activation time (VAT) between groups. Conclusions: CAE ECGs were found to be associated with increased Tp-Te, Tp-Te/QT ratio, QTc intervals and P-wave dispersions. This may suggest that CAE existence has a pro-arrhythmogenic nature. Cardiol Res. 2017;8(6):280-285 doi: https://doi.org/10.14740/cr631w |
| Databáze: | OpenAIRE |
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