Isocratic, simultaneous normal-phase LC separation of four impurities for a stavudine synthesis control

Autor:	Helena Kazoka, Marina Madre
Rok vydání:	2005
Předmět:	Chromatography Normal phase Stavudine Ethyl acetate Analytical chemistry Silica column Analytical Chemistry chemistry.chemical_compound chemistry Impurity Stationary phase Phase (matter) medicine Ethylene glycol medicine.drug
Zdroj:	Talanta. 67:98-102
ISSN:	0039-9140
DOI:	10.1016/j.talanta.2005.02.023
Popis:	The isocratic separation of impurities for a stavudine synthesis control has been studied by liquid chromatography (LC). The investigations have shown that isocratic reversed-phase LC conditions were unable to achieve a good separation. It was established that isocratic normal-phase LC system with common silica column as a stationary phase and the mixture of ethyl acetate with 4% (v/v) of ethylene glycol as a mobile phase is useful in simultaneous determination of four impurities for a stavudine synthesis control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84e9fa65410294fc072f399ada2ef4 https://doi.org/10.1016/j.talanta.2005.02.023 Zobrazit plný text záznamu Full Text from ScienceDirect