The Predictive Value of N-Terminal Probrain Natriuretic Peptide for Infection in Patients With Acute Myocardial Infarction
| Autor: | Pengcheng He, Yuanhui Liu, Jijin Lin, Ling Xue, Li-Tao Wang, Shuai Shao, Yining Dai, Chong-Yang Duan, XiaoLiang Wan, Jiyan Chen, Ning Tan, HongHuan Chen, Can Liu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment acute myocardial infarction predictor Cardiovascular Medicine Internal medicine Clinical endpoint Natriuretic peptide medicine Diseases of the circulatory (Cardiovascular) system Myocardial infarction cardiovascular diseases Risk factor Original Research business.industry percutaneous coronary intervention Percutaneous coronary intervention Odds ratio medicine.disease infection N-terminal probrain natriuretic peptide RC666-701 Conventional PCI Cardiology and Cardiovascular Medicine business Mace |
| Zdroj: | Frontiers in Cardiovascular Medicine Frontiers in Cardiovascular Medicine, Vol 8 (2021) |
| ISSN: | 2297-055X |
| Popis: | Background: Infections increase the risk of poor outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). However, predicting patients at a high risk of developing infection remains unclear. Moreover, the value of N-terminal probrain natriuretic peptide (NT-proBNP) for predicting infection is still unknown. Thus, we aimed to assess the relationship between NT-proBNP and the following development of infection, and clinical adverse outcomes in patients with STEMI undergoing PCI.Methods: STEMI patients undergoing PCI were consecutively enrolled from January 2010 to July 2016 and divided into groups according to baseline NT-proBNP levels: tertiles T1 (Results: A total of 182 (27%) patients developed in-hospital infection. The incidence of infection increased from T1 to T3 (10.5, 17.7, and 54.5%, P < 0.001). NT-proBNP was an independent risk factor (adjusted odds ratio = 1.39, 95% confidence interval (CI) = 1.12–1.73, P = 0.003) and presented accurately predicting infection (area under curve = 0.774). Multivariate cox analysis showed that NT-proBNP was a significant risk factor for major adverse clinical events (MACE) at follow-up (adjusted HR = 1.92, 95% CI = 1.61–2.29, P < 0.001).Conclusion: The baseline NT-proBNP level has a good predictive value for infection and MACE in STEMI patients undergoing PCI. |
| Databáze: | OpenAIRE |
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