Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine
| Autor: | I. I. Faingold, B. S. Fedorov, A. B. Eremeev, A. V. Smolina, Yu. V. Soldatova, R. A. Kotel’nikova, D. A. Poletaeva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Free Radicals Monoamine oxidase General Biochemistry Genetics and Molecular Biology Antioxidants Catalysis law.invention 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine law Animals Monoamine Oxidase Structural analog Chemiluminescence chemistry.chemical_classification biology Myocardium Cell Membrane Fatty acid Heart General Medicine Mice Inbred C57BL 030104 developmental biology Membrane chemistry Biochemistry Liposomes Luminescent Measurements Picolines biology.protein Phosphatidylcholines Pyrene Lipid Peroxidation Monoamine oxidase A 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 167(6) |
| ISSN: | 1573-8221 |
| Popis: | We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes with pyrene in the region of fatty acid tails of phospholipids. Luminol-amplified chemiluminescence analysis showed that both compounds exhibited antiradical activity and in a concentration of 0.1 mM reduced chemiluminescence intensity by more than 70%. 2-Nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine inhibited catalytic activity of monoamine oxidase A more efficiently than its structural analogue Mexidol. |
| Databáze: | OpenAIRE |
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